Judging from traffic on Technologizer this week, a ton of folks are at least giving Chrome a try. If you've used it, I'd love to hear your thoughts; if you haven't used it, I'd love to hear why...
It worked great running a single window, but I didn't like how it handled tabs. It seemed to completely stop scripting on the background tabs, effectively preventing them from loading in the background, and it's my habit to open links in new background tabs, giving them a chance to load before I view them. It took quite awhile to switch between tabs too.